Cell atlas. Showing subcellular location of SMIM1 (Vel). We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies.

Gene information about ENSG00000235169 / SMIM1 - small integral membrane protein 1 (Vel blood group)

Small Integral Membrane. The SMIM1 gene codes for the Vel antigen. The Vel negative phenotype is caused by a homozygous 17 base pair deletion in exon 3 of the SMIM1 gene which 034, VEL, Vel, SMIM1, protein, v1.0 (160620). 035, CD59, CD59, CD59, protein, v2.0 01-MAR-2020. 036, AUG, Augustine, SLC29A1, protein, 8th April 2019.

ESPN. COL4A1. RNASE9. SLC6A9. RABL6 . Personen mit dem Phänotyp „Vel-negativ“ weisen auf Chromosom 1 eine homozygo- te Deletion im Gen für das „Small Integral. Membrane Protein 1“ ( SMIM1) Ouwehand and Prof Mattia Frontini, I investigated the role of SMIM1 protein in blood cells and other organs, using an in vivo and in vitro approach, and three 9, 2019, article, Prevalence of SMIM1 c.64_80del17 homozygotes in southeastern Brazil: the Vel-negative phenotype, 1, 1.

SMIM1. small integral membrane protein 1 (Vel blood group) 30 Oct 2020 Weak Vel expression can be caused by mutations within SMIM1 in a heterozygous setting, suggesting a dominant negative effect of SMIM1 The genetic background of the Vel blood group has been a mystery for decades.

Smim1 - Small integral membrane protein 1 - Mus musculus (Mouse) - Smim1 gene & protein UniProtKB - P0C8K7 (SMIM1_MOUSE)

RABL6 . Personen mit dem Phänotyp „Vel-negativ“ weisen auf Chromosom 1 eine homozygo- te Deletion im Gen für das „Small Integral.

Phenotype data for mouse gene Smim1. Discover Smim1's significant phenotypes, expression, images, histopathology and more. Data for gene Smim1 is all freely available for download.

The schematic of the SMIM1 protein with I-TASSER predicted 3D-structure showing the extracellular domain SMIM1.

The cancer tissue page shows antibody staining of the protein in 20 different cancers. FAQs for SMIM1 Antibody (NBP2-38120). (Showing 1 - 1 of 1 FAQ). May I know whether this Ab can be used for FACS? Our antibody NBP2-38120 has not yet been tested in flow cytometry or FACS.
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Summary of SMIM1 expression in human tissue. Cytoplasmic expression in several tissues, with additional membranous expression in few tissues.

small integral membrane protein 1 (Vel blood group) 30 Oct 2020 Weak Vel expression can be caused by mutations within SMIM1 in a heterozygous setting, suggesting a dominant negative effect of SMIM1 The genetic background of the Vel blood group has been a mystery for decades.
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Identifying SMIM1, SMall Integral Membrane protein 1, as the protein encoding the Vel antigen has significantly improved the identification of Vel negative donors. These rare donors are essential for safe blood transfusions.

The Vel antigen is present on red blood cells from all people except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in … 2013-06-03 Identifying SMIM1, SMall Integral Membrane protein 1, as the protein encoding the Vel antigen has significantly improved the identification of Vel negative donors.

Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype. Jill Storry , Magnus Jöud , Mikael Kronborg Christophersen , Britt Thuresson , Bo Åkerström , Birgitta Nilsson Sojka , Björn Nilsson & Martin L Olsson , 2013 , In : Nature Genetics. 45 , 5 , p. 537-U109

0.4. 0.6. 0.8. 1 un sp lice d. Smim1 data model. 95% c.i.. 0.5.

These antibodies may cause severe hemolytic reactions in blood recipients. Abstract Disruption of SMIM1, encoding small integral membrane protein 1, is responsible for the Vel-negative blood type, a rare but clinically-important blood type. However, the exact nature of the Vel antigen and how it is presented by SMIM1 are poorly understood. Smim1 - Small integral membrane protein 1 - Mus musculus (Mouse) - Smim1 gene & protein UniProtKB - P0C8K7 (SMIM1_MOUSE) Identifying SMIM1, SMall Integral Membrane protein 1, as the protein encoding the Vel antigen has significantly improved the identification of Vel negative donors. These rare donors are essential for safe blood transfusions. The Vel blood group is associated with the SMIM1 gene, which is located in the 1p36 region of chromosome 1.